Associate Scientist-High Throughput Purification

Associate Scientist in High Throughput Purification (HTP) Lab – Spring House, PA

Job Description:

Spectrix is seeking a highly motivated BS- or MS-level chemist with small molecule analytical and purification skills to work in our laboratories to advance drug discovery programs toward the clinic. The Associate Scientist will support purification operations in a high‑throughput discovery environment. This role is responsible for routine operation and maintenance of HPLC/MS and SFC/MS systems, performing small‑molecule and peptide purifications, and downstream sample handling including assay ready solution preparation, and ensuring safe, organized lab operations. The ideal candidate is hands‑on, detail oriented, and experienced with chromatography and mass spectrometry workflows. She/he will maintain close interactions with scientists from Discovery Chemistry, Discovery Process Chemistry and Parallel Medicinal Chemistry teams to expedite the compound design-synthesis-test iterations. Strong people skills and the ability to thrive in a team and goal driven environment are key attributes.

Responsibilities:

• Conduct daily system suitability check on analytical and preparative HPLC/MS, SFC/MS

• Perform preliminary method screening experiments, HPLC/MS and SFC/MS–based purifications of small molecules and peptides, post purification QC and downstream handling.

• Maintain instrument in good working condition and perform troubleshooting analysis and maintenance as required; coordinate repairs and preventive maintenance with service provider when needed

• Support lab operations and maintain general lab orderliness

• Assist in the maintenance of a safe working environment and operate in a safe manner

• Other duties and assignments as needed to support the lab operations

Qualifications:

• A minimum of a bachelor's degree in Analytical, Synthetic, Organic, Medicinal chemistry or related chemistry degree is required

• Minimum of 2 years analytical or purification HPLC/SFC with mass spectrometry experience required

• Knowledge of modern chromatography techniques, such as HPLC or SFC with MS detector experience.

• Experience with Waters equipment with Masslynx software preferred

• Independent thinking and the ability to effectively collaborate in a highly matrixed environment

• Must be detail oriented with strong organization/communication skills and have good documentation practices

Spectrix offers flexible schedules, competitive salaries, and a committed work environment to its employees; the company provides automatic benefits of life insurance and short and long term disability insurance. Optional benefits for full time employees include health, dental, and vision insurance, college loan assistance, and an employer matched retirement savings plan. Spectrix is not a placement agency.

Spectrix is an equal-opportunity employer. We do not discriminate on the basis of race,color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Spectrix complies with all applicable federal, state, and local laws governing nondiscrimination in employment.

Pay: $ $33.00 per hour

Benefits:

• 401(k)
• 401(k) matching
• Commuter assistance
• Dental insurance
• Employee assistance program
• Health insurance
• Health savings