Scientist II, ASO Process Development and Manufacturing

About This Role   

We are looking for a highly motivated and creative Scientist II to join our Oligonucleotide Chemical Development team. This role offers an exciting opportunity to contribute to the development of robust processes for synthesizing oligonucleotides. As part of this team, you will gain hands-on experience in designing and developing manufacturing processes for clinical and commercial therapeutics. You will play a pivotal role in optimizing synthesis processes, focusing on enhancing process robustness, productivity, and impurity control. Your work will have a significant impact on advancing our therapeutic capabilities, fitting into the broader mission of delivering innovative solutions to improve patient lives.

What You'll Do   

• Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize and/or characterize the synthesis processes of oligonucleotides with an emphasis on improvement in process robustness and productivity and control of impurities.

• Perform pilot-scale syntheses to produce oligonucleotide compounds for purification process development and/or preclinical studies.

• Record the experimental procedures and data accurately.

• Communicate research results effectively by writing research reports and presenting data in team meetings.

• Engage in the CMC activities including authoring CMC section of INDs.

• Manage the Contract Research Organization (CRO)

• Initiate innovative research projects to improve synthesis processes.

Who You Are   

You have a passion for exploring novel scientific concepts and are eager to contribute to developing cutting-edge technologies in oligonucleotide synthesis. Your vision and dedication drive you to push the boundaries of Biogen's scientific endeavors, ultimately impacting patient lives. You thrive in a collaborative environment and are committed to advancing innovative solutions.

Required Skills   

• Specialization in synthetic organic chemistry with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.

• Ph.D. with 0-3 years of relevant postdoc experience.

• M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.

• BS with 6+ years of relevant experience in pharmaceutical or biotech settings

• Ability to perform synthetic process research and development of drug candidates including conjugates and starting materials beyond platform oligonucleotides by using information from literature, conferences, seminars etc.

• Knowledge in patent applications and manuscripts for publications.

• Ability to work independently and collaboratively within a team environment.

• Effective communication skills in both written and oral forms.

Preferred Skills  

• Experience in nucleoside chemistry or oligonucleotide synthesis 

• Experience in API synthesis process development

Additional Information

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. 

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement 
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance 
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit 
• 401(k) program participation with company matched contributions
• Employee stock purchase plan 
• Tuition reimbursement of up to $10,000 per calendar year 
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.