Director/Sr. Director, Manufacturing

Company Overview:

Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform with integrated gene editing, delivery and internal manufacturing capabilities. Beam's suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Position Overview:

Beam is looking for a highly energetic Director / Senior Director, Manufacturing, to lead our internal manufacturing team.  The Director / Senior Director, Manufacturing will be responsible for teams manufacturing multiple modalities, including mRNA, Lipid Nanoparticles, and Autologous Cell Therapy, for clinical and commercial supply.   As a key member of the North Carolina Site Leadership Team, the individual will develop and implement operational strategies to build a nimble, flexible, efficient operation and ensure safe and reliable supply.  The ideal candidate will be a seasoned leader with a demonstrated track record of building high performing teams.  They will also possess the ability to interface successfully with multidisciplinary teams and build strong cross-functional relationships. 

Responsibilities:

• Cultivate Beam's culture and our values-driven organization focused on people.
• Define and implement the mission, vision, and strategy for Beam internal cGMP Manufacturing, supporting both clinical and commercial operations.
• Ensure safety, compliance, efficiency, and sustainability throughout cGMP operations.
• Lead and coordinate resources to ensure quality standards are met and products are delivered on time and within budget.
• Champion development of a learning culture that embraces innovation and continuous improvement.
• Prepare and maintain departmental budget and workforce model.
• Support establishment of long range and business continuity plans.
• Develop and implement metrics/KPIs to monitor operational health, inform strategic decisions, and present materials at management reviews.
• Build collaborative and empowered teams that put patients first.
• Recruit, retain, and develop high-performing and diverse teams.
• Represent department during audits and regulatory inspections.
• Establish and maintain strong relationships at the site and cross-functionally.
• Assures alignment of internal manufacturing schedules with product supply forecasts and program timelines.
• Develops and maintains detailed manufacturing project plans, defines risks, and establishes contingency plans to ensure projects are delivered on time, within budget, and adhere to high quality standards.
• Support facility and equipment design and qualification for ability to meet process and regulatory expectations.
• Contributes to development and implementation of manufacturing documents (batch records, procedures, and technical reports).
• Lead and/or assist with manufacturing deviation investigations and change controls.
• Supports tech