Scientist, Analytical Development

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit , and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

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• Lead analytical method development and qualification/validation activities for the characterization of antibody and antibody conjugate utilizing various analytical techniques including but not limited to SEC-UPLC, RP-UPLC, HILIC-UPLC, IEX-UPLC, HIC-UPLC, Mixed Mode-UPLC, 2D-LC, CE-SDS, iCIEF, Bioassays (ELISA, cell based assays), qPCR, LC-MS, NGS

• Support cell line development to enable faster and informed decision making when needed. Key analytical areas for cell line development include but are not limited to high throughput titer analysis, purity analysis, N-glycan analysis, charge variant analysis, sequence variant analysis, genomic integrity analysis

• Represent analytical development on CMC cross-functional teams and maintain accountability for analytical deliverables

• Lab Personnel and ensure laboratory safety practices

• Support off-site analytical method transfers, manufacturing support, and interaction with external vendors when needed

• Leverage literature, ICH/Regulatory guidance, and practical experience to perform this work and influence CMC development strategies

• Other duties as assigned

• BS/BA degree in chemistry or closely related field and 2+ years of pharmaceutical industry experience in an R&D/QC setting, including conducting HPLC analysis and troubleshooting, evaluating analytical data and drawing meaningful conclusions OR

• MS/MA degree in chemistry or closely related field preferred and some similar industry experience noted above OR

• PhD in chemistry or closely related field and some industry or relevant experience a plus

• Expert knowledge and understanding of analytical chemistry and a thorough understanding of antibody bioprocess including cell line development, upstream development, downstream development, and formulation development

• Extensive experience and expertise with antibody modalities, focusing on analytical development

• Proficient in characterization of antibody modalities using various analytical technologies including but not limited to liquid chromatography (SEC, HILIC, RP, HIC, AEX, CEX), capillary electrophoresis (Maurice, PA800+, Labchip GX/GXII, etc.), imaged capillary isoelectric focusing (Maurice), gel electrophoresis, mass spectrometry, ELISA, bioassays, molecular analysis (southern blot, northern blot, NGS, etc.)

• Method development, qualification, validation, and