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Principal Scientist
Congruence Therapeutics
- Montreal, Québec, Canada
- Montreal, Québec, Canada
About
Congruence Therapeutics is a biotechnology company working at the interface of computational and experimental drug discovery to design novel small molecules for diseases of protein misfolding. Using structural bioinformatics, computational chemistry, and machine learning, the Company is deploying an in silico platform that enables the design of new pharmacological stabilizers, a validated class of small molecules, at an unprecedented speed and scale.
Role Description
This is a full-time on-site role for an experienced Principal Scientist, based in the Greater Montreal Metropolitan Area. The candidate will use a combination of cell biology and molecular pharmacology, together with Congruence Therapeutics' proprietary platform technology RevenirTM, to study diseases caused by protein misfolding leading to destabilization, aberrant signaling and/or trafficking defects of the target protein. The candidate will serve as subject matter expert to the Company's project teams. Experience with small molecule screening and/or pharmacological chaperones/stabilizing drugs will be considered as a strong asset. The selected candidate will also help shape the structure/culture of their biology team and contribute to the company's collaborative, supportive, and dynamic environment.
Qualifications
Ph.D. in a relevant discipline with 8-10 years of drug discovery experience in a pharmaceutical or biotech environment; or MS/MSC with 10-15 years of similar experience
Strong background in assay development and compound testing/screening for various types of targets (ex. GPCR, ion channel, transporter, receptor, enzyme)
Experience in leading multidisciplinary drug discovery project teams in diverse therapeutic areas and molecular target classes
Experience with pharmacological chaperones or stabilizing drugs is desirable
Team player and mentor, listens effectively, and invites response and discussion
Excellent interpersonal, oral, and written communication skills (clear, thorough, timely, and consistent)
Demonstrated initiative and innovative thinking both individually and within a multidisciplinary team environment
Ability to rapidly acquire new skills, as needed.
Responsibilities
Provide subject matter expertise in cell and molecular biology in support of drug discovery programs
Drive scientific innovation, excellence and rigor to support drug discovery programs at all stages, from Hit Validation to Development Candidate nomination
Translate understanding of the target/genotype/phenotype relationship to develop disease-relevant in vitro and ex vivo biological assays (including biophysical, target engagement, cellular and functional assays)
Keep abreast of emerging developments in the fields of protein misfolding, stabilization, and small molecule drug discovery
Evaluate emerging technologies and methods to ensure our research plan is innovative, scientifically sound and efficient
Proactively identify risks as they arise and propose mitigation plans
Ensure that Biology data are appropriately presented and interpreted and that questions are addressed in a timely manner
Critically analyze and interpret complex data sets, utilizing appropriate statistical tools
Define realistic timelines for studies to meet aggressive deadlines within budget
Manage collaborative relationships with key internal and external stakeholders to properly resource/advance portfolio projects and help teams reach key decision points
Manage activities and cultivate relationships with external CROs to ensure high quality deliverables and adherence to planned timelines/budgets
Lead, manage, develop, and retain a high-performance team, providing development opportunities and mentorship, as necessary
Generate publications in leading journals and present findings at key scientific meetings, as required
Attributes That Will Make You Successful At Congruence
Passionate and curious
Drug hunter mentality driven by the desire to deliver new medicines to underserved patients
Excitement for using and creating novel technologies and processes
Strong team spirit and interpersonal skills, and interest in working with highly talented individuals in a fast-paced, collaborative, goal-oriented environment
Strong sense of engagement, ownership, accountability, professionalism, scientific integrity and independence
We Offer
A meritocracy that is committed to delivering new medicines to underserved patients
The opportunity to work innovatively at the interface of the dry lab and wet lab
The prospect of getting in on the ground floor and making your mark
Highly competitive base compensation and incentive pay
Stock options
Premium benefits including health, dental, and vision
Telehealth
RRSP match
Flexible policies
Modern labs in an exciting environment
Languages
- English
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