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Advisor - Oligonucleotide AnalyticsBioSpace • Boston, Massachusetts, United States
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Advisor - Oligonucleotide Analytics

BioSpace
  • US
    Boston, Massachusetts, United States
  • US
    Boston, Massachusetts, United States
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About

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
The Lilly Genetic Medicine RNA group at Lilly Seaport Innovation Center in Boston is seeking a highly skilled and motivated Analytical Scientist to join our team. The successful candidate will bring a strong track record in designing, developing, and implementing analytical and separation methodologies for the characterization and quality control of oligonucleotides and their conjugates. This is a predominantly lab-based role requiring deep expertise in LC and LC-MS method development, a solid understanding of oligonucleotide synthesis and downstream processing, and a commitment to advancing the science of complex, chemically modified oligonucleotides in support of RNA therapeutics.
Responsibilities
Design, develop, optimize, and standardize robust analytical and separation methods—including LC, LC-MS, CE, SEC/AEX-MALS and preparative HPLC systems—for sample quality control and the characterization of oligonucleotides and their conjugates across all stages of drug discovery.
Proactively evaluate and implement innovative analytical technologies to address challenges in the analysis of complex, modified oligonucleotides and drive continuous scientific advancement.
Maintain and troubleshoot analytical and separation instrumentation (e.g., UPLC, LC-MS, CE, and preparative HPLC) to ensure high performance, reliability, and minimal downtime in support of critical workflows.
Leverage deep expertise in oligonucleotide characterization and quality control to strengthen internal capabilities through the adoption of advanced instrumentation—including fit-for-purpose instrument re-engineering—for open-access use and analytical R&D applications; lead protocol development, technical coaching, team mentorship, and strategic direction.
Partner with IT to build and maintain laboratory informatics systems that ensure efficient data acquisition, processing, traceability, and integrity using appropriate analytical software.
Continuously refine existing analytical methods and assays, driving innovation as needed to meet evolving program requirements.
Collaborate across chemistry, biology, and technology platform teams to develop novel workflows that support the exploration of new chemical modalities for RNA therapeutics.
Rapidly integrate new technologies and apply cross-disciplinary scientific concepts to resolve complex analytical challenges.
Maintain thorough, accurate, and prompt documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports.
Uphold high standards of laboratory practice in compliance with safety and quality guidelines, promoting operational excellence across all analytical activities.
Communicate findings and progress clearly and persuasively through regular presentations at project team, departmental, and governance meetings.
Basic Qualifications
PhD in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related scientific field
1-4+ years of relevant post-graduate experience (including industry postdoctoral experience).
Additional Skills & Preferences
Extensive experience in LC and LC-MS method development, optimization, and troubleshooting.
Proficiency in the characterization of chemically modified oligonucleotides, conjugates, and related impurities.
Understanding of structure–activity relationships (SAR) and developability assessments for therapeutic oligonucleotides.
Analytical Method Development and Innovation
Proven track record in developing and validating a broad range of analytical and separation techniques, including LC, LC-MS, ion-pairing LC, SEC, CE, HILIC, HIC, and IEX.
Demonstrated ability to assess and adopt emerging analytical technologies, such as high-resolution mass spectrometry, oligonucleotide mapping, intact mass analysis, and charge variant analysis.
Instrumentation Proficiency
Hands‑on experience operating, maintaining, and troubleshooting analytical and separation platforms, including UPLC, LC-MS, CE, MALS, and preparative HPLC.
Familiarity with Agilent and Thermo instrumentation and associated software, including ChemStation, OpenLab CDS, MassHunter, and Xcalibur.
Analytical Strategy and Quality Perspective
Solid knowledge of analytical control strategies and quality standards applicable across early- and late-stage drug discovery.
Scientific Ownership and Initiative
High degree of self‑motivation with a demonstrated ability to independently lead and deliver complex scientific projects.
Communication and Collaboration
Strong written and verbal communication skills, with the ability to collaborate effectively across cross‑functional teams.
Adaptability and Project Management
Open‑minded, meticulous, and committed to continuous learning in a fast‑paced, dynamic environment.
Proven ability to manage multiple priorities, navigate ambiguity, and deliver high-quality results under tight timelines.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $138,000 - $224,400.
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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  • Boston, Massachusetts, United States

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  • English
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